Professional background

Professor John Duncan qualified from Oxford University Medical School with BM BCh in 1979, MA in 1980, DM in 1988. 

He was elected FRCP (Fellowship of the Royal Society of Physicians) in 1994 and FMedSci in 2005. Since July 1989,he has been a consultant neurologist, with a particular interest in epilepsy, to the National Hospital for Neurology and Neurosurgery, Queen Square, and the National Society for Epilepsy. In this role, he has approximately 2,000 patients under his clinical review.

He is an National Institute of Health and Care Research senior Investigator and has previously been medical director of The Epilepsy Society, clinical director of the Queen Square Division of UCLH, and president of the UK Chapter of The International League against Epilepsy. 

Research interests

Epilepsy and brain imaging


  • De Tisi J, Bell GS, Peacock JL, McEvoy AW, Harkness WFJ, Sander JW, Duncan JS. The long-term outcome of adult epilepsy surgery, patterns of seizure remission and relapse: a cohort study. Lancet. 2011 Oct 15;378(9800):1388-95. PubMed PMID: 22000136.
  • Winston GP, Daga P, Stretton J, Modat M, Symms MR, McEvoy AW, Ourselin S, Duncan JS. Optic radiation tractography and vision in anterior temporal lobe resection. Ann Neurol. 2012 Mar;71(3):334-41. doi: 10.1002/ana.22619. PubMed PMID: 22451201.
  • Bonelli SB, Thompson PJ, Yogarajah M, Powell RH, Samson RS, McEvoy AW, Symms MR, Koepp MJ, Duncan JS. Memory reorganization following anterior temporal lobe resection: a longitudinal functional MRI study. Brain. 2013 Jun;136(Pt 6):1889-900. doi: 10.1093/brain/awt105. Epub 2013 May 28. PubMed PMID: 23715092; PubMed Central PMCID: PMC3673465.
  • Sidhu MK, Stretton J, Winston GP, Bonelli S, Centeno M, Vollmar C, Symms M, Thompson PJ, Koepp MJ, Duncan JS. A functional magnetic resonance imaging study mapping the episodic memory encoding network in temporal lobe epilepsy. Brain. 2013 Jun;136(Pt 6):1868-88. doi: 10.1093/brain/awt099. Epub 2013 May 14. PubMed PMID: 23674488; PubMed Central PMCID: PMC3673458.
  • Sidhu MK, Stretton J, Winston GP, Symms M, Thompson PJ, Koepp MJ, Duncan JS. Memory fMRI predicts verbal memory decline after anterior temporal lobe resection. Neurology. 2015 Apr 14;84(15):1512-9. pii: 10.1212/WNL.0000000000001461. [Epub ahead of print] PubMed PMID: 25770199. Central PMCID: PMC4408284.
  • Duncan JS, Winston GP, Koepp MJ, Ourselin S. Brain imaging in the assessment for epilepsy surgery. Lancet Neurology 2016: Feb 23. pii: S1474-4422(15)00383-X. doi: 10.1016/S1474-4422(15)00383-X. [Epub ahead of print] Review. PubMed PMID: 26925532.
  • Sidhu MK, Stretton J, Winston GP, McEvoy AW, Symms M, Thompson PJ , Koepp MJ, Duncan JS. Memory network plasticity after temporal lobe resection: a longitudinal functional imaging study. Brain. 2016 Jan 10. pii: awv365. [Epub ahead of print] PubMed PMID: 26754787.
  • Bell GS, de Tisi J, Gonzalez-Fraile JC, Peacock JL, McEvoy AW, Harkness WFJ, Foong J, Pope RA, Diehl B, Sander JW, Duncan JS. Factors affecting seizure outcome after epilepsy surgery: an observational series. J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):933-940. PubMed PMID: 28870986.
  • Taylor PN, Sinha N, Wang Y, Vos SB, de Tisi J, Miserocchi A, McEvoy AW, Winston GP, Duncan JS. The impact of epilepsy surgery on the structural connectome and its relation to outcome. Neuroimage Clin. 2018 Jan 31;18:202-214. doi: 10.1016/j.nicl.2018.01.028. eCollection 2018. PubMed PMID: 29876245; PubMed Central PMCID: PMC5987798.
  • Vakharia VN, Sparks R, Rodionov R, Vos SB, Dorfer C, Miller J, Nilsson D, Tisdall M, Wolfsberger S, McEvoy AW, Miserocchi A, Winston GP, O'Keeffe AG, Ourselin S, Duncan JS. Computer-assisted planning for the insertion of stereoelectroencephalography electrodes for the investigation of drug-resistant focal epilepsy: an external validation study. J Neurosurg. 2018 Apr 13:1-10. Doi: 10.3171/2017.10.JNS171826. [Epub ahead of print] PubMed PMID: 29652234.
  • Trimmel K, van Graan AL, Caciagli L, Haag A, Koepp MJ, Thompson PJ, Duncan JS. Left temporal lobe language network connectivity in temporal lobe epilepsy. Brain 2018 Aug 1;141(8):2406-2418. PubMed PMID: 29939211.
  • Li K, Vakharia VN, Sparks R, Franca LGS, Granados A, McEvoy AW, Miserocchi A, Wang M, Ourselin S, Duncan JS. Optimizing Trajectories for Cranial Laser Interstitial Thermal Therapy Using Computer-Assisted Planning: A Machine Learning Approach. Neurotherapeutics. 2019 Jan;16(1):182-191. doi: 10.1007/s13311-018-00693-1. Review. PubMed PMID: 30520003; PubMed Central PMCID: PMC6361073.
  • Vakharia VN, Sparks RE, Li K, O'Keeffe AG, Pérez-García F, França LGS, Ko AL, Wu C, Aronson JP, Youngerman BE, Sharan A, McKhann G 2nd, Ourselin S, Duncan JS. Multicenter validation of automated trajectories for selective laser amygdalohippocampectomy. Epilepsia. 2019 Aug 7. doi: 10.1111/epi.16307. [Epub ahead of print] PubMed PMID: 31392717.
  • Trimmel K, van Graan LA, Gonzálvez GG, Haag A, Caciagli L, Vos SB, Bonelli S, Sidhu M, Thompson PJ, Koepp MJ, Duncan JS. Naming fMRI predicts the effect of temporal lobe resection on language decline. Ann Clin Transl Neurol. 2019 Nov;6(11):2186-2196 PubMed PMID: 31578819.
  • Vos SB, Winston GP, Goodkin O, Pemberton HG, Barkhof F, Prados F, Galovic M, Koepp M, Ourselin S, Cardoso MJ, Duncan JS. Hippocampal profiling: Localized magnetic resonance imaging volumetry and T2 relaxometry for hippocampal sclerosis. Epilepsia. 2020 Feb;61(2):297-309. doi: 10.1111/epi.16416. Epub 2019 Dec 24. PubMed PMID: 31872873; PubMed Central PMCID: PMC7065164.
  • Trimmel K, Caciagli L, Xiao F, van Graan LA, Koepp MJ, Thompson PJ, Duncan JS. Impaired naming performance in temporal lobe epilepsy: language fMRI responses are modulated by disease characteristics. J Neurol. 2020 Aug 3. doi: 10.1007/s00415-020-10116-x. PMID: 32747979.