Donanemab for early onset Alzheimer's

Before Donanemab can be offered as a treatment option, patients will need to be assessed to check whether the drug is appropriate for their use.

The prices shown below outline the costs for this assessment stage, followed by the packages of care during treatment, including in-hospital infusions and subsequent stay-at-home infusions.

Patients may not need each assessment stage, for example if they have already had some tests and investigations done elsewhere. Tests will only be repeated if clinically necessary.

If Donanemab is not considered to be a suitable treatment option at any stage in the assessment process, patients will proceed to the next assessment stage.

Assessment packages
Packages	Price	Description
Pre-assessment triage	£150	Patients who have not previously seen one of the dementia specialist consultants here will need to have a pre-assessment triage with a nurse specialist. Any required blood tests will be charged on top of this fee.
First consultation	£480	After the initial pre-assessment triage, patients will be booked for a consultation with one of our dementia specialist consultants to discuss the treatment and what it means in more detail.
Eligibility assessment	£6,250	Patients who are still considered potentially eligible for Donanemab treatment after their consultation will need to undertake a set of further tests to confirm eligibility. This will include an ApoE blood test, an MRI brain scan, and either a lumbar puncture or Amyloid PET scan. This may require a further consultation with the lead consultant (additional fee of £280), and in some people a neuropsychology assessment (additional fee of circa £600, depending on consultant). Please note – if patients have previously had some of these tests and investigations at UCLH or elsewhere and they don’t need repeating the fees will be removed from the above package and won’t be charged.
Multidisciplinary team (MDT) eligibility meeting	£960	Prior to the start of treatment, a team of consultants will undertake a final review of the patient’s case to assess whether the patient is suitable for treatment.

Treatment packages

Package prices	Price	Description
In-hospital infusion	First infusion - £3,300 Second infusion - £4,200 Third infusion - £5,100 All other infusions - £6000	Patients will receive four-weekly infusions in hospital for the first six months of treatment. During the first four infusions the dosage of Donanemab is slowly increased. The increased dosage is reflected in the increased price per infusion. Each infusion package price includes a telephone pre-assessment with a nurse specialist, the hospital admission, an infusion of Donanemab, and a follow-up telephone call with a nurse specialist. MRI scans are required before the 2^nd, 4^th, and 7^th infusion and are separately chargeable. Patients are reviewed by their consultant every two months during this stage of treatment. There is an additional charge of £280 per review.
At-home infusion	£4,150 per infusion	After six months of treatment in hospital, the treatment will continue every 4 weeks in the patient’s own home. This is delivered by a healthcare-at-home provider in partnership with UCLH. This package will include the infusion of the drug but exclude any consultations.

Package prices

Price

Description

In-hospital infusion

First infusion - £3,300

Second infusion - £4,200

Third infusion - £5,100

All other infusions - £6000

Patients will receive four-weekly infusions in hospital for the first six months of treatment. During the first four infusions the dosage of Donanemab is slowly increased. The increased dosage is reflected in the increased price per infusion.

Each infusion package price includes a telephone pre-assessment with a nurse specialist, the hospital admission, an infusion of Donanemab, and a follow-up telephone call with a nurse specialist.

MRI scans are required before the 2^nd, 4^th, and 7^th infusion and are separately chargeable.

Patients are reviewed by their consultant every two months during this stage of treatment. There is an additional charge of £280 per review.

At-home infusion

£4,150 per infusion

After six months of treatment in hospital, the treatment will continue every 4 weeks in the patient’s own home. This is delivered by a healthcare-at-home provider in partnership with UCLH. This package will include the infusion of the drug but exclude any consultations.

The combined cost of 18 months of infusions of Donanemab including hospital and homecare is £87,550.

Our expert team of clinical nurse specialists (CNS) will support the patient throughout their treatment journey. This is included in the pricing packages above.

Other costs


Additional consultant reviews	£280	Patients will have periodic reviews with their consultant after the first six months of treatment.

Exclusions

After treatment has commenced, if an MRI scan shows brain swelling or small brain bleeds, known as ARIA, then treatment is paused. Additional MRI scans, review by the consultant team, and consultations will be required and will be charged in addition to the above packages.

Any additional treatment in hospital beyond the delivery of Donanemab will be charged at standard rates.

Indicative prices for assessment and treatment including all consultant fees and scans

Eligibility and work up

	Charges
Pre-assessment triage and blood tests	£650
Initial consultation	£480
Eligibility assessment including consultations and MDT	£8,090
Total	£9,220

18 month treatment

	Charges
In-hospital infusions x 6	£33,600
Routine MRI scans	£3,750
At-home infusions x 13	£53,950
Consultant reviews x 3	£840
Total	£92,140

To enquire further please contact uclh.private.enquiries@nhs.net or call us on 020 3448 4260.

Donanemab for early onset Alzheimer's - price list

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Assessment packages